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Specialized technology:

Our strong chemistry: Friedel Crafts reaction, Bromination reaction, Chlorination reaction, Grignard reaction,

Coupling reaction, Chiral asymmetric synthesis(including asymmetric reduction, alkylation), Heterocyclic

compounds synthesis, Reduction reaction, Hockman re-arrangement reaction, as well as other basic regular

reactions.



Friedel-Crafts reaction

Friedel Crafts is classical synthesis method of acylation processes.

Some examples:

Ar-H+R-COCl?Ar-CO-R+HCl

Grignard reaction

Grignard reaction is classical synthesis method of alkylation's processes. We routinely prepares and makes 

use of Grignard reagents for the manufacture of intermediates and active ingredients for the markets of 

Pharmaceuticals and chemicals. Syntheses are performed at scales between some tens of kg and more than 

500kg per batch because of local dry air condition.

R-X+Mg?R-MgX


RMgX + H2O ? RH + Mg(OH)X

RMgX + ROH ? RH + ROMgX

RMgX + RCOOH ? RH + RCOOMgX

RMgX + NH3 ? RH + NH2MgX

RMgX + RNH2 ? RH + RNHMgX

RMgX + RC=CH ? RH + RC=CMgX


Bromination reaction

Bromination reaction is classical synthesis method of Bromide series. 

CH3COOC2H5 + Br2 ? BrCH2COOC2H5 + HBr

ClCH2C=CH + HBr ? ClCH2CH2CH2Br

3 RCOOH + PBr3 ? 3 RCOBr + HP(O)(OH)2


Acyl chlorination

Sulfuryl dichloride, oxalyl dichloride, chlorine gas and chlorine hydride are often used as chloride agent. 

Some examples :

R-COOH + SOCl2 ? R-COCl + SO2 + HCl

R-COOH + PCl3 ? R-COCl + HOPCl2


 

Nitration

Organic compounds in molecules into nitro (-NO2) reaction. Aromatics of nitration is the preparation of 

aromatic nitro-compound the most important methods. Nitration reagent have nitric acid and denitration acyl 

bittern (NOX), four fluorine boric acid nitro cation, etc, and most important, the most commonly used is the 

mixture of sulfuric acid and nitric acid. 

Ar-H+HNO3?Ar-NO2+H2O 

C7H8 + HNO3 ? C7H7NO2 + H2O


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